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ATXN2 Rabbit Polyclonal Antibody (CAB16666)

SKU:
CAB16666
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 7 Anti-ATXN2 Antibody CAB16666
  • Cell Biology Antibodies 7 Anti-ATXN2 Antibody CAB16666
  • Cell Biology Antibodies 7 Anti-ATXN2 Antibody CAB16666
  • Cell Biology Antibodies 7 Anti-ATXN2 Antibody CAB16666
  • Cell Biology Antibodies 7 Anti-ATXN2 Antibody CAB16666
€139 - €419
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Description

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ATXN2 Rabbit Polyclonal Antibody (CAB16666)

The ATXN2 Polyclonal Antibody (CAB16666) is specifically designed for research involving ATXN2, a protein involved in RNA metabolism and neurodegenerative diseases such as spinocerebellar ataxia type 2. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in various applications including Western blot and immunohistochemistry.ATXN2 is a critical factor in RNA processing and has been linked to the pathology of neurodegenerative diseases. The ATXN2 Polyclonal Antibody binds specifically to the ATXN2 protein, allowing for its detection and analysis in various cell types and tissues.

This makes it an invaluable tool for researchers studying the role of ATXN2 in neurological disorders and RNA metabolism.Understanding the function and regulation of ATXN2 is essential for developing targeted therapies for neurodegenerative diseases associated with this protein. The ATXN2 Polyclonal Antibody provides researchers with a reliable tool to further investigate the role of ATXN2 in disease pathology and potential therapeutic interventions.

Product Name:ATXN2 Rabbit Polyclonal Antibody
SKU:CAB16666
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1250-1331 of human ATXN2 (NP_002964.3).
Sequence:HVQS GMVP SHPT AHAP MMLM TTQP PGGP QAAL AQSA LQPI PVST TAHF PYMT HPSV QAHH QQQL
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200
Synonyms:ATX2; SCA2; TNRC13; ATXN2
Positive Sample:Rat uterus
Conjugate:Unconjugated
Cellular Localization:Cytoplasm.
Calculated MW:140kDa
Observed MW:150kDa

This gene belongs to a group of genes that is associated with microsatellite-expansion diseases, a class of neurological and neuromuscular disorders caused by expansion of short stretches of repetitive DNA. The protein encoded by this gene has two globular domains near the N-terminus, one of which contains a clathrin-mediated trans-Golgi signal and an endoplasmic reticulum exit signal. The encoded cytoplasmic protein localizes to the endoplasmic reticulum and plasma membrane, is involved in endocytosis, and modulates mTOR signals, modifying ribosomal translation and mitochondrial function. The N-terminal region of the protein contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues. Intermediate length expansions of this tract increase susceptibility to amyotrophic lateral sclerosis, while long expansions of this tract result in spinocerebellar ataxia-2, an autosomal-dominantly inherited, neurodegenerative disorder. Genome-wide association studies indicate that loss-of-function mutations in this gene may be associated with susceptibility to type I diabetes, obesity and hypertension. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:6311
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from Rat uterus, using ATXN2 Rabbit pAb (CAB16666) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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