The ATXN1L Polyclonal Antibody (PAC04826) is a valuable tool for researchers studying the ATXN1L protein, a key player in neurodegenerative diseases such as spinocerebellar ataxia type 1-like (SCA1-L). This antibody, produced in rabbits, is highly specific to human ATXN1L samples and has been validated for use in Western blot applications.ATXN1L is a protein associated with RNA metabolism and transcription regulation, and its dysregulation has been linked to neurodegenerative disorders characterized by progressive cerebellar ataxia.
By targeting the ATXN1L protein, researchers can gain insights into the molecular mechanisms underlying these diseases and potentially identify novel therapeutic targets.This polyclonal antibody allows for the detection and analysis of ATXN1L expression in various cell types, making it an invaluable tool for studies in neuroscience and neurology. By elucidating the role of ATXN1L in disease pathology, researchers can contribute to the development of effective treatments for neurodegenerative conditions like SCA1-L.
Antibody Name:
ATXN1L Antibody (PACO48246)
Antibody SKU:
PACO48246
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Ataxin-1-like protein (183-463AA)
Immunohistochemistry of paraffin-embedded human brain tissue using PACO48246 at dilution of 1:100.
Background:
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1) (By similarity).
Synonyms:
Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1), ATXN1L, BOAT BOAT1
UniProt Protein Function:
ataxin-1L: Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). Belongs to the ATXN1 family.Chromosomal Location of Human Ortholog: 16q22.2Cellular Component: nucleolus; nucleoplasm; nucleusMolecular Function: protein binding
