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ATXN1 Rabbit Polyclonal Antibody (CAB6217)

SKU:
CAB6217
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
  • Epigenetics and Nuclear Signaling Antibodies 2 Anti-ATXN1 Antibody CAB6217
  • Epigenetics and Nuclear Signaling Antibodies 2 Anti-ATXN1 Antibody CAB6217
€139 - €419
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Description

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ATXN1 Rabbit Polyclonal Antibody (CAB6217)

The Ataxin-1 Polyclonal Antibody (CAB6217) is a valuable tool for researchers studying Ataxin-1, a protein involved in neurodegenerative disorders such as Spinocerebellar ataxia type 1 (SCA1). The antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting Ataxin-1 in human samples, making it ideal for use in various research techniques, including Western blot analysis.Ataxin-1 is known to play a crucial role in the development of SCA1, a genetic disorder characterized by progressive loss of coordination and movement.

By targeting Ataxin-1, researchers can better understand the mechanisms underlying SCA1 and potentially identify new therapeutic strategies for treating the disease. The Ataxin-1 Polyclonal Antibody provides a reliable tool for studying Ataxin-1 expression and function in both normal and diseased tissues, advancing our knowledge of neurodegenerative disorders.

Product Name:ATXN1 Rabbit Polyclonal Antibody
SKU:CAB6217
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 586-815 of human ATXN1 (NP_001121636.1).
Sequence:ELKK VEDL KTED FIQS AEIS NDLK IDSS TVER IEDS HSPG VAVI QFAV GEHR AQVS VEVL VEYP FFVF GQGW SSCC PERT SQLF DLPC SKLS VGDV CISL TLKN LKNG SVKK GQPV DPAS VLLK HSKA DGLA GSRH RYAE QENG INQG SAQM LSEN GELK FPEK MGLP AAPF LTKI EPSK PAAT RKRR WSAP ESRK LEKS EDEP PLTL PKPS LIPQ EVKI CIEG RSNV GK
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:ATX1; SCA1; D6S504E; ATXN1
Positive Sample:A-431,293T,HT-29,NCI-H460,SKOV3,Mouse brain,Mouse heart,Mouse lung,Rat brain
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:87kDa
Observed MW:87kDa

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 40-83 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). Alternative splicing results in multiple transcript variants, with one variant encoding multiple distinct proteins, ATXN1 and Alt-ATXN1, due to the use of overlapping alternate reading frames.

Purification Method:Affinity purification
Gene ID:6310
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using ATXN1 antibody (CAB6217) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 120s.

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