ATRX Polyclonal Antibody (CAB17378)
- SKU:
- CAB17378
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | ATRX Polyclonal Antibody |
SKU: | CAB17378 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 2100-2200 of human ATRX (NP_000480.3). |
Sequence: | EEFN DETN VRGR LFII STKA GSLG INLV AANR VIIF DASW NPSY DIQS IFRV YRFG QTKP VYVY RFLA QGTM EDKI YDRQ VTKQ SLSF RVVD QQQV ERHF T |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:2000 - 1:6000 |
Synonyms: | JMS; XH2; XNP; MRX52; RAD54; RAD54L; ZNF-HX; ATRX |
Positive Sample: | HeLa,Mouse brain |
Cellular Localization: | nuclear body, nuclear chromosome, nucleoplasm, nucleus, PML body |
Calculated MW: | 283kDa |
Observed MW: | 310kDa |
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
Purification Method: | Affinity purification |
Gene ID: | 546 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |