The ATR Rabbit Polyclonal Antibody (CAB17294) is a crucial tool for researchers studying the ATR protein, a key player in the DNA damage response pathway. This antibody, generated in rabbits, has high specificity and sensitivity for detecting ATR in human samples, allowing for accurate analysis in Western blot applications.ATR, or Ataxia Telangiectasia and Rad3-related protein, is essential for maintaining genomic stability and preventing the accumulation of DNA damage. Dysregulation of ATR function has been implicated in various diseases, including cancer and neurological disorders.
By targeting ATR, researchers can gain insights into the mechanisms underlying these diseases and potentially discover novel therapeutic strategies.The ATR Rabbit Polyclonal Antibody is a valuable tool for researchers working in the fields of molecular biology, oncology, and genetics. Its ability to selectively bind to ATR protein enables precise detection and quantification, making it an indispensable asset for investigating the role of ATR in DNA repair pathways and disease development.
Product Name:
ATR Rabbit Polyclonal Antibody
SKU:
CAB17294
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 740-870 of ATR (NP_001175.2).
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
Purification Method:
Affinity purification
Gene ID:
545
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunofluorescence analysis of C6 cells using ATR Rabbit pAb (CAB17294) at dilution of 1:100. Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
