The ATR Polyclonal Antibody (CAB7247) is a powerful tool for researchers studying the ataxia telangiectasia and Rad3-related protein (ATR), a key player in DNA damage response pathways. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting ATR in human samples, making it an invaluable tool for experiments involving Western blotting.ATR is a crucial protein involved in maintaining genomic stability and preventing the accumulation of mutations that can lead to cancer development. By targeting ATR with this polyclonal antibody, researchers can gain insights into the role of ATR in DNA damage repair and cell cycle checkpoint control.
This knowledge is essential for developing targeted therapies for cancer treatment and understanding the mechanisms underlying chemotherapy resistance.The ATR Polyclonal Antibody (CAB7247) is an essential resource for scientists studying DNA damage response pathways and aiming to uncover new therapeutic strategies for cancer and other related diseases. Its high specificity and reliability make it a valuable asset for research in molecular biology, oncology, and drug development.
Product Name:
ATR Rabbit Polyclonal Antibody
SKU:
CAB7247
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 400-650 of human ATR (NP_001175.2).
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
Purification Method:
Affinity purification
Gene ID:
545
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of NCI-H460 cells, using ATR Antibody (CAB7247) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
