The ATR Monoclonal Antibody (CAB21253) is a valuable tool for researchers studying the ATR protein, a key player in the DNA damage response pathway. This antibody, produced through monoclonal antibody technology, demonstrates high specificity and sensitivity in detecting ATR in a variety of sample types, including human cells.ATR is a crucial protein involved in maintaining genomic stability and preventing the accumulation of mutations that can lead to cancer and other genetic disorders. By targeting ATR with this monoclonal antibody, researchers can explore the role of ATR in DNA repair processes, cell cycle regulation, and response to genotoxic stress.
The ATR Monoclonal Antibody (CAB21253) is ideal for use in techniques such as Western blotting, immunoprecipitation, and immunofluorescence, providing researchers with a versatile tool for investigating the functions and interactions of ATR in different experimental settings. Its application in cancer research, genetic studies, and drug development makes it a valuable asset for laboratories focused on understanding the complexities of the DNA damage response.
Product Name:
ATR Monoclonal Antibody
SKU:
CAB21253
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 2100-2200 of human ATR (NP_001175.2).
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
Purification Method:
Affinity purification
Gene ID:
545
Clone Number:
ARC51749
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ATR antibody (CAB21253) at1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
