ATR Monoclonal Antibody (CAB21253)
- SKU:
- CAB21253
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Frequently bought together:
Description
Product Name: | ATR Monoclonal Antibody |
SKU: | CAB21253 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 2100-2200 of human ATR (NP_001175.2). |
Sequence: | KAYE WEKA GRSD RVQM RNDL GKIN KVIT EHTN YLAP YQFL TAFS QLIS RICH SHDE VFVV LMEI IAKV FLAY PQQA MWMM TAVS KSSY PMRV NRCK EILN K |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | FRP1; MEC1; SCKL; FCTCS; SCKL1; ATR |
Positive Sample: | A-431,Mouse testis |
Conjugate: | Unmodified |
Cellular Localization: | Chromosome, Nucleus, PML body. |
Calculated MW: | 301kDa |
Observed MW: | 301kDa |
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
Purification Method: | Affinity purification |
Gene ID: | 545 |
Clone Number: | ARC51749 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |