ATR Rabbit Polyclonal Antibody (CAB13951)
- SKU:
- CAB13951
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | ATR Rabbit Polyclonal Antibody |
SKU: | CAB13951 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 400-500 of human ATR (NP_001175.2). |
Sequence: | LKME SMEI IEEI QCQT QQEN LSSN SDGI SPKR RRLS SSLN PSKR APKQ TEEI KHVD MNQK SILW SALK QKAE SLQI SLEY SGLK NPVI EMLE GIAV VLQL T |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | FRP1; MEC1; SCKL; FCTCS; SCKL1; ATR |
Positive Sample: | HeLa,293F |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Nucleus, PML body. |
Calculated MW: | 301kDa |
Observed MW: | 301kDa |
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
Purification Method: | Affinity purification |
Gene ID: | 545 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |