The ATPase ASNA1 Polyclonal Antibody (CAB3746) is a valuable tool for researchers studying ASNA1, an essential protein involved in protein folding and insertion into the endoplasmic reticulum membrane. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for Western blot applications. By binding specifically to the ASNA1 protein, researchers can detect and analyze its expression in various cell types, making it an ideal choice for studies in cell biology and protein metabolism.ASNA1, also known as ATPase ASNA1 or TRC40, is a key player in the cellular process of co-translational protein targeting to the endoplasmic reticulum. Dysregulation of ASNA1 function has been linked to various diseases, including neurodegenerative disorders and certain cancers.
Investigating the role of ASNA1 is crucial for understanding its involvement in these pathological conditions and for developing potential therapeutic interventions targeting protein folding and trafficking pathways.Overall, the ATPase ASNA1 Polyclonal Antibody (CAB3746) is a valuable resource for researchers seeking to delve deeper into the intricate mechanisms of protein biogenesis and cellular homeostasis. Its specificity and reliability make it an indispensable tool for studies focusing on ASNA1 and its impact on various physiological and pathological processes.
Product Name:
ASNA1 Rabbit Polyclonal Antibody
SKU:
CAB3746
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-348 of human ASNA1 (NP_004308.2).
This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion.
Purification Method:
Affinity purification
Gene ID:
439
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ASNA1 antibody (CAB3746) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
