The ATP9A Polyclonal Antibody (PAC051338) is a valuable tool for researchers studying ATP9A, a protein involved in cellular processes related to energy metabolism and ion transport. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By specifically binding to the ATP9A protein, this antibody enables the detection and analysis of ATP9A expression in a variety of cell types, making it an ideal choice for studies in biochemistry and molecular biology.ATP9A has been implicated in various physiological functions, including the maintenance of cellular energy balance and the regulation of ion gradients across cell membranes.
Dysregulation of ATP9A has been linked to disorders such as metabolic diseases and neurodegenerative conditions, underscoring the importance of studying this protein in both normal and pathological contexts. The ATP9A Polyclonal Antibody provides researchers with a reliable tool for investigating the role of ATP9A in health and disease, ultimately facilitating the development of targeted therapies and diagnostic strategies.
Western Blot. Positive WB detected in: MCF-7 whole cell lysate, HepG2 whole cell lysate. All lanes: ATP9A antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 119, 106 kDa. Observed band size: 119 kDa..
Immunohistochemistry of paraffin-embedded human testis tissue using PACO51338 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human brain tissue using PACO51338 at dilution of 1:100.
Background:
early endosome, perinuclear region of cytoplasm, plasma membrane, recycling endosome, trans-Golgi network, phospholipid-translocating ATPase activity, endocytosis, phospholipid translocation, retrograde vesicle-mediated transport, Golgi to ER
Synonyms:
Probable phospholipid-transporting ATPase IIA (EC 3.6.3.1) (ATPase class II type 9A), ATP9A, ATPIIA KIAA0611
UniProt Protein Function:
Catalytic activity: ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).Subcellular location: Early endosome membrane; Multi-pass membrane protein. Recycling endosome. Golgi apparatus › trans-Golgi network membrane. Note: Efficient exit from the endoplasmic reticulum does not require TMEM30A, nor TMEM30B. Ref.5Sequence similarities: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]Sequence caution: The sequence BAD18775.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI18889.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI19203.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI22924.1 differs from that shown. Reason: Erroneous gene model prediction.
