The ATP8B3 Polyclonal Antibody (CAB17834) is a valuable tool for research focused on ATP8B3, a key protein involved in lipid transport and maintaining cell membrane integrity. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for Western blot analysis among other applications.ATP8B3, a member of the P-type ATPase family, plays an essential role in lipid metabolism and translocation, particularly in liver cells where it regulates bile acid secretion. Dysregulation of ATP8B3 has been linked to various liver disorders, highlighting its importance in maintaining hepatocellular function.
Researchers investigating liver diseases, lipid disorders, and membrane transport mechanisms will find this antibody invaluable for detecting and studying ATP8B3 expression in different cell types and tissues.By using the ATP8B3 Polyclonal Antibody, scientists can gain deeper insights into the physiological functions of ATP8B3 and its potential implications in liver pathology. This antibody opens up opportunities for elucidating the molecular mechanisms underlying lipid homeostasis and cell membrane dynamics, paving the way for future therapeutic interventions targeting ATP8B3-related disorders.
Product Name:
ATP8B3 Rabbit Polyclonal Antibody
SKU:
CAB17834
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 600-900 of human ATP8B3 (NP_620168.1).
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to the other. This gene encodes member 3 of phospholipid-transporting ATPase 8B; other members of this protein family are located on chromosomes 1, 15 and 18. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
148229
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HCT116 cells, using ATP8B3 Rabbit pAb (CAB17834) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
