ATP8A2 Antibody (PACO48730)
- SKU:
- PACO48730
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
ATP8A2 Antibody (PACO48730)
The ATP8A2 Polyclonal Antibody (PACO48730) is a valuable tool for researchers studying ATP8A2, a protein involved in lipid transport and membrane organization. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it suitable for use in various research applications, including Western blotting.ATP8A2, a member of the P4-ATPase family, plays a crucial role in maintaining lipid asymmetry in cell membranes and is essential for cellular functions such as membrane fusion and vesicle trafficking. Dysregulation of ATP8A2 has been implicated in various diseases, including neurodegenerative disorders and cancer, making it a promising target for therapeutic intervention.
By utilizing the ATP8A2 Polyclonal Antibody, researchers can investigate the expression and localization of ATP8A2 in different cell types and tissues, enabling a better understanding of its function and potential implications in disease pathogenesis. This antibody serves as a valuable tool for studies in cell biology, lipid metabolism, and disease mechanisms, furthering our knowledge of ATP8A2 and its role in various biological processes.
| Antibody Name: | ATP8A2 Antibody (PACO48730) |
| Antibody SKU: | PACO48730 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Phospholipid-transporting ATPase IB protein (358-570AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO48730 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO48730 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Involved in regulation of neurite outgrowth; acting in synergy with TMEM30A. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival. |
| Synonyms: | Phospholipid-transporting ATPase IB (EC 3.6.3.1) (ATPase class I type 8A member 2) (ML-1) (P4-ATPase flippase complex α subunit ATP8A2), ATP8A2, ATPIB |
| UniProt Protein Function: | ATP8A2 iso1: Belongs to the cation transport ATPase (P-type) family. Type IV subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter, ion channel; Membrane protein, multi-pass; Hydrolase; EC 3.6.3.1; Cell cycle regulation; Membrane protein, integral; TransporterChromosomal Location of Human Ortholog: 13q12Cellular Component: Golgi apparatus; plasma membrane; trans-Golgi networkMolecular Function: phospholipid-translocating ATPase activityBiological Process: Golgi vesicle budding; negative regulation of cell proliferation; neuron developmentDisease: Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 4 |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the P4 ATPase family of proteins, which are thought to be involved in a process called lipid flipping, whereby phospholipids are translocated inwards from the exoplasmic leaflet to the cytosolic leaflet of the cell membrane, which aids in generating and maintaining asymmetry in membrane lipids. This protein is predicted to contain an E1 E2 ATPase, a haloacid dehalogenase-like hydrolase (HAD) domain, and multiple transmembrane domains. Associations between this protein and cell cycle control protein 50A are important for translocation of phosphatidylserine across membranes. Mutations in this gene have been associated with cerebellar ataxia, mental retardation and disequilibrium syndrome (CAMRQ). In addition, a translocation breakpoint within this gene was observed in an individual with neurological dysfunction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015] |
| UniProt Code: | Q9NTI2 |
| NCBI GenInfo Identifier: | 30316390 |
| NCBI Gene ID: | 51761 |
| NCBI Accession: | Q9NTI2.2 |
| UniProt Secondary Accession: | Q9NTI2,Q9H527, Q9NPU6, Q9NTL2, Q9NYM3 |
| UniProt Related Accession: | Q9NTI2 |
| Molecular Weight: | 59,296 Da |
| NCBI Full Name: | Phospholipid-transporting ATPase IB |
| NCBI Synonym Full Names: | ATPase phospholipid transporting 8A2 |
| NCBI Official Symbol: | ATP8A2Â Â |
| NCBI Official Synonym Symbols: | IB; ATP; ML-1; ATPIB; CAMRQ4Â Â |
| NCBI Protein Information: | phospholipid-transporting ATPase IB |
| UniProt Protein Name: | Phospholipid-transporting ATPase IB |
| UniProt Synonym Protein Names: | ATPase class I type 8A member 2; ML-1; P4-ATPase flippase complex alpha subunit ATP8A2 |
| Protein Family: | Phospholipid-transporting ATPase |
| UniProt Gene Name: | ATP8A2Â Â |
| UniProt Entry Name: | AT8A2_HUMAN |
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