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ATP8A2 Antibody (PACO48730)

SKU:
PACO48730
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • ATP8A2 Antibody PACO48730
  • ATP8A2 Antibody PACO48730
€359

Description

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ATP8A2 Antibody (PACO48730)

The ATP8A2 Polyclonal Antibody (PACO48730) is a valuable tool for researchers studying ATP8A2, a protein involved in lipid transport and membrane organization. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it suitable for use in various research applications, including Western blotting.ATP8A2, a member of the P4-ATPase family, plays a crucial role in maintaining lipid asymmetry in cell membranes and is essential for cellular functions such as membrane fusion and vesicle trafficking. Dysregulation of ATP8A2 has been implicated in various diseases, including neurodegenerative disorders and cancer, making it a promising target for therapeutic intervention.

By utilizing the ATP8A2 Polyclonal Antibody, researchers can investigate the expression and localization of ATP8A2 in different cell types and tissues, enabling a better understanding of its function and potential implications in disease pathogenesis. This antibody serves as a valuable tool for studies in cell biology, lipid metabolism, and disease mechanisms, furthering our knowledge of ATP8A2 and its role in various biological processes.

Antibody Name:ATP8A2 Antibody (PACO48730)
Antibody SKU:PACO48730
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC, IF
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Phospholipid-transporting ATPase IB protein (358-570AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunohistochemistry of paraffin-embedded human testis tissue using PACO48730 at dilution of 1:100.
Product ImageImmunofluorescent analysis of HepG2 cells using PACO48730 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Involved in regulation of neurite outgrowth; acting in synergy with TMEM30A. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.
Synonyms:Phospholipid-transporting ATPase IB (EC 3.6.3.1) (ATPase class I type 8A member 2) (ML-1) (P4-ATPase flippase complex α subunit ATP8A2), ATP8A2, ATPIB
UniProt Protein Function:ATP8A2 iso1: Belongs to the cation transport ATPase (P-type) family. Type IV subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter, ion channel; Membrane protein, multi-pass; Hydrolase; EC 3.6.3.1; Cell cycle regulation; Membrane protein, integral; TransporterChromosomal Location of Human Ortholog: 13q12Cellular Component: Golgi apparatus; plasma membrane; trans-Golgi networkMolecular Function: phospholipid-translocating ATPase activityBiological Process: Golgi vesicle budding; negative regulation of cell proliferation; neuron developmentDisease: Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 4
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a member of the P4 ATPase family of proteins, which are thought to be involved in a process called lipid flipping, whereby phospholipids are translocated inwards from the exoplasmic leaflet to the cytosolic leaflet of the cell membrane, which aids in generating and maintaining asymmetry in membrane lipids. This protein is predicted to contain an E1 E2 ATPase, a haloacid dehalogenase-like hydrolase (HAD) domain, and multiple transmembrane domains. Associations between this protein and cell cycle control protein 50A are important for translocation of phosphatidylserine across membranes. Mutations in this gene have been associated with cerebellar ataxia, mental retardation and disequilibrium syndrome (CAMRQ). In addition, a translocation breakpoint within this gene was observed in an individual with neurological dysfunction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
UniProt Code:Q9NTI2
NCBI GenInfo Identifier:30316390
NCBI Gene ID:51761
NCBI Accession:Q9NTI2.2
UniProt Secondary Accession:Q9NTI2,Q9H527, Q9NPU6, Q9NTL2, Q9NYM3
UniProt Related Accession:Q9NTI2
Molecular Weight:59,296 Da
NCBI Full Name:Phospholipid-transporting ATPase IB
NCBI Synonym Full Names:ATPase phospholipid transporting 8A2
NCBI Official Symbol:ATP8A2  
NCBI Official Synonym Symbols:IB; ATP; ML-1; ATPIB; CAMRQ4  
NCBI Protein Information:phospholipid-transporting ATPase IB
UniProt Protein Name:Phospholipid-transporting ATPase IB
UniProt Synonym Protein Names:ATPase class I type 8A member 2; ML-1; P4-ATPase flippase complex alpha subunit ATP8A2
Protein Family:Phospholipid-transporting ATPase
UniProt Gene Name:ATP8A2  
UniProt Entry Name:AT8A2_HUMAN
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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