| UniProt Protein Function: | ATP6V1F: Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the V-ATPase F subunit family.Protein type: HydrolaseChromosomal Location of Human Ortholog: 7q32Cellular Component: cytosol; membrane; vacuolar proton-transporting V-type ATPase complexMolecular Function: ATPase activity, coupled to transmembrane movement of ions; protein bindingBiological Process: insulin receptor signaling pathway; transferrin transport |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16864 |
| NCBI GenInfo Identifier: | 126302612 |
| NCBI Gene ID: | 9296 |
| NCBI Accession: | Q16864.2 |
| UniProt Secondary Accession: | Q16864,Q6IBA8, C9J2K4 |
| UniProt Related Accession: | Q16864 |
| Molecular Weight: | 16,402 Da |
| NCBI Full Name: | V-type proton ATPase subunit F |
| NCBI Synonym Full Names: | ATPase H+ transporting V1 subunit F |
| NCBI Official Symbol: | ATP6V1FÂ Â |
| NCBI Official Synonym Symbols: | VATF; Vma7; ATP6S14Â Â |
| NCBI Protein Information: | V-type proton ATPase subunit F |
| UniProt Protein Name: | V-type proton ATPase subunit F |
| UniProt Synonym Protein Names: | V-ATPase 14 kDa subunit; Vacuolar proton pump subunit F |
| Protein Family: | |
| UniProt Gene Name: | ATP6V1FÂ Â |
| UniProt Entry Name: | VATF_HUMAN |
