The ATP6V1F Polyclonal Antibody (PACO07941) is a valuable tool for researchers studying ATP6V1F, a subunit of the vacuolar ATPase enzyme complex involved in proton transport across membranes. This antibody is raised in rabbits and is highly specific to human ATP6V1F samples, making it ideal for Western blot applications.ATP6V1F is essential for maintaining cellular pH and membrane trafficking, playing a key role in various cellular processes such as endocytosis, lysosomal degradation, and autophagy. Its dysregulation has been implicated in diseases like osteoporosis, neurodegenerative disorders, and cancer.
The ATP6V1F Polyclonal Antibody enables the detection and analysis of ATP6V1F protein levels in different cell types, allowing researchers to further understand its function and potential therapeutic implications in disease treatment. By utilizing this antibody, researchers can explore the role of ATP6V1F in cellular physiology and disease pathogenesis, ultimately contributing to the development of novel approaches for targeting ATP6V1F-related pathways in clinical settings.
ATP6V1F: Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the V-ATPase F subunit family.Protein type: HydrolaseChromosomal Location of Human Ortholog: 7q32Cellular Component: cytosol; membrane; vacuolar proton-transporting V-type ATPase complexMolecular Function: ATPase activity, coupled to transmembrane movement of ions; protein bindingBiological Process: insulin receptor signaling pathway; transferrin transport
UniProt Protein Details:
NCBI Summary:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein. [provided by RefSeq, Jul 2008]
