ATP6V1C1 Rabbit Polyclonal Antibody (CAB18253)
- SKU:
- CAB18253
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | ATP6V1C1 Rabbit Polyclonal Antibody |
SKU: | CAB18253 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300-382 of human ATP6V1C1 (NP_001686.1). |
Sequence: | LRVF VESV LRYG LPVN FQAM LLQP NKKT LKKL REVL HELY KHLD SSAA AIID APMD IPGL NLSQ QEYY PYVY YKID CNLL EFK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | VATC; Vma5; ATP6C; ATP6D; ATP6V1C1 |
Positive Sample: | U-251MG,293T,Mouse kidney |
Cellular Localization: | cytosol, extracellular exosome, extrinsic component of synaptic vesicle membrane, plasma membrane |
Calculated MW: | 44kDa |
Observed MW: | 43kDa |
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D.
Purification Method: | Affinity purification |
Gene ID: | 528 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |