ATP6V1B1 Rabbit Polyclonal Antibody (CAB6876)
- SKU:
- CAB6876
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
Product Name: | ATP6V1B1 Rabbit Polyclonal Antibody |
SKU: | CAB6876 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ATP6V1B1 (NP_001683.2). |
Sequence: | MAME IDSR PGGL PGSS CNLG AARE HMQA VTRN YITH PRVT YRTV CSVN GPLV VLDR VKFA QYAE IVHF TLPD GTQR SGQV LEVA GTKA IVQV FEGT SGID ARKT TCEF TGDI LRTP VSED MLGR VFNG SGKP IDKG PVVM AEDF LDIN GQPI NPHS RIYP EEMI QTGI SPID VMNS IARG QKIP IFSA AGLP HNEI AAQI CRQA GLVK KSKA VLDY HDDN FAIV FAAM GVNM ETAR FFKS DFEQ NGTM GNVC LFLN LAND PTIE RIIT PRLA LTTA EFLA |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | VATB; VMA2; VPP3; DRTA2; RTA1B; ATP6B1; ATP6V1B1 |
Positive Sample: | BT-474,MCF7,HepG2,Mouse testis,Mouse kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Endomembrane system, Peripheral membrane protein. |
Calculated MW: | 57kDa |
Observed MW: | 57kDa |
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness.
Purification Method: | Affinity purification |
Gene ID: | 525 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |