The ATP6V0C Polyclonal Antibody (CAB16350) is a powerful tool for researchers studying ATP6V0C, a vital component of the V-type H+-ATPase complex essential for proton transportation across membranes. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting ATP6V0C in human samples, making it a reliable choice for Western blot analyses.ATP6V0C plays a key role in maintaining cellular pH balance and regulating endocytic and secretory pathways. Dysregulation of ATP6V0C has been linked to various diseases, including osteopetrosis and renal tubular acidosis.
The ATP6V0C Polyclonal Antibody enables precise detection and quantification of ATP6V0C levels in different cell types, making it an invaluable tool for researchers investigating the molecular mechanisms underlying these pathologies.By utilizing the ATP6V0C Polyclonal Antibody in their studies, researchers can gain valuable insights into the functions of ATP6V0C and its implications in disease pathology. This antibody is a valuable asset for research in cell biology, physiology, and the development of potential therapeutic interventions targeting ATP6V0C-related disorders.
Product Name:
ATP6V0C Rabbit Polyclonal Antibody
SKU:
CAB16350
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ATP6V0C (NP_001185498.1).
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17.
Purification Method:
Affinity purification
Gene ID:
527
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using ATP6V0C Rabbit pAb (CAB16350) at 1:1000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime: 60s.
