The ATP6V0A1 Polyclonal Antibody (CAB15258) is a valuable tool for researchers studying ATP6V0A1, a subunit of the V-type H+-ATPase complex involved in proton transport across membranes. This antibody, produced in rabbits, specifically targets ATP6V0A1 and is highly reactive with human samples. Validated for use in Western blot applications, the ATP6V0A1 Polyclonal Antibody enables the detection and analysis of the ATP6V0A1 protein in various cell types.ATP6V0A1 is essential for cellular processes such as acidification of intracellular compartments and lysosome function. Dysregulation of ATP6V0A1 has been linked to diseases including osteopetrosis, renal tubular acidosis, and cancer.
By studying ATP6V0A1 with this antibody, researchers can gain insights into its role in disease development and potentially identify new therapeutic targets related to proton transport and lysosomal acidification.Overall, the ATP6V0A1 Polyclonal Antibody is a valuable asset for researchers interested in exploring the functions and implications of ATP6V0A1 in health and disease. Its high specificity and reactivity make it an ideal choice for studies in cell biology, cancer biology, and other research areas where ATP6V0A1 is implicated.
Product Name:
ATP6V0A1 Rabbit Polyclonal Antibody
SKU:
CAB15258
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 60-300 of human ATP6V0A1 (NP_001123493.1).
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
535
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunofluorescence analysis of HeLa cells using ATP6V0A1 Rabbit pAb (CAB15258) at dilution of 1:100. Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
