The Renin Receptor Polyclonal Antibody (CAB6531) is a vital tool for researchers studying the renin receptor, a key player in the renin-angiotensin system that regulates blood pressure and fluid balance. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By targeting the renin receptor protein, this antibody allows for precise detection and analysis in various cell types, making it essential for studies in cardiovascular biology and hypertension research.The renin receptor, also known as ATP6AP2, is a crucial component in the renin-angiotensin system, which plays a significant role in maintaining blood pressure and electrolyte balance.
Dysregulation of this system has been implicated in various cardiovascular diseases, including hypertension and heart failure. By studying the renin receptor, researchers can gain valuable insights into the mechanisms underlying these conditions and develop targeted therapies to treat them effectively.Overall, the Renin Receptor Polyclonal Antibody (CAB6531) serves as a valuable tool for investigating the renin-angiotensin system and its role in cardiovascular health. Its high reactivity and specificity make it an ideal choice for researchers looking to deepen their understanding of this critical regulatory pathway.
Product Name:
ATP6AP2 Rabbit Polyclonal Antibody
SKU:
CAB6531
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 251-350 of human ATP6AP2 (NP_005756.2).
This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases.
Purification Method:
Affinity purification
Gene ID:
10159
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ATP6AP2 antibody (CAB6531) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
