The ATP6 Polyclonal Antibody (CAB8193) is a vital tool for research involving ATP6, a key component of the mitochondrial ATP synthase complex responsible for generating energy in cells. This antibody is produced through immunization of rabbits and exhibits high reactivity with human samples, making it suitable for use in Western blot applications. By targeting the ATP6 protein, this antibody enables researchers to detect and analyze ATP6 levels in various cell types, facilitating studies in bioenergetics, metabolism, and mitochondrial function.ATP6, a subunit of the ATP synthase complex, plays a crucial role in cellular energy production through oxidative phosphorylation. Dysregulation of ATP6 has been implicated in various diseases, including mitochondrial disorders, neurodegenerative diseases, and cancer.
Investigating ATP6 expression and function can provide valuable insights into the mechanisms underlying these conditions and aid in the development of targeted therapeutics aimed at restoring mitochondrial function and cellular energy balance.Overall, the ATP6 Polyclonal Antibody is a valuable resource for researchers interested in exploring the roles of ATP6 in health and disease. Its specificity and reliability make it an essential tool for studies focused on mitochondrial biology, energy metabolism, and the development of novel therapeutic strategies targeting ATP6-related pathways.
Product Name:
ATP6 Rabbit Polyclonal Antibody
SKU:
CAB8193
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 127-226 of mouse ATP6 (NP_904333.1).
Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in mitochondrial ATP synthesis coupled proton transport. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; heart; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; NARP syndrome; Parkinson's disease; multiple sclerosis; and systemic lupus erythematosus. Orthologous to human MT-ATP6 (mitochondrially encoded ATP synthase membrane subunit 6).
Purification Method:
Affinity purification
Gene ID:
17705
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from HepG2 cells, using ATP6 Rabbit pAb (CAB8193) at 1:2000ï¼›1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
