The ATP2B2 Polyclonal Antibody (CAB6875) is a valuable tool for researchers studying ATP2B2, a plasma membrane calcium-transporting ATPase involved in controlling calcium levels within cells. This antibody, produced in rabbits, exhibits high reactivity with human samples and is specifically validated for use in Western blot applications. By binding to the ATP2B2 protein, this antibody allows for the detection and analysis of ATP2B2 expression in various cell types, making it ideal for investigations in cell biology and neuroscience.ATP2B2 plays a crucial role in maintaining cellular calcium homeostasis, a key process for proper cell function and signaling.
Dysregulation of ATP2B2 has been implicated in various disorders, including neurological diseases and cardiovascular conditions. By understanding the function of ATP2B2, researchers can uncover its potential as a therapeutic target for diseases related to calcium signaling pathways. Overall, the ATP2B2 Polyclonal Antibody is a valuable resource for scientists looking to delve into the complex mechanisms of cellular calcium regulation and its implications in disease development and progression.
Product Name:
ATP2B2 Rabbit Polyclonal Antibody
SKU:
CAB6875
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human ATP2B2 (NP_001674.2).
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
491
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of SH-SY5Y cells, using ATP2B2 antibody (CAB6875) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
