ATP2B1 Rabbit Polyclonal Antibody (CAB18688)
- SKU:
- CAB18688
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | ATP2B1 Rabbit Polyclonal Antibody |
SKU: | CAB18688 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human ATP2B1 (NP_001673.2). |
Sequence: | QESY GDVY GICT KLKT SPNE GLSG NPAD LERR EAVF GKNF IPPK KPKT FLQL VWEA LQDV TLII LEIA AIVS LGLS FYQP PEGD NALC GEVS VGEE EGEG E |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | MRD66; PMCA1; PMCA1kb; ATP2B1 |
Positive Sample: | Mouse brain |
Cellular Localization: | apical plasma membrane, basolateral plasma membrane, cytoplasmic side of plasma membrane, extracellular exosome, GABA-ergic synapse, glutamatergic synapse, immunological synapse, nucleoplasm, photoreceptor ribbon synapse, plasma membrane, presynaptic active zone membrane, presynaptic membrane, synaptic vesicle membrane |
Calculated MW: | 135kDa |
Observed MW: | 140kDa |
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method: | Affinity purification |
Gene ID: | 490 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |