SERCA2/ATP2A2 Rabbit Polyclonal Antibody (CAB1097)
- SKU:
- CAB1097
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | SERCA2/ATP2A2 Rabbit Polyclonal Antibody |
SKU: | CAB1097 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence within amino acids 1-80 of human SERCA2/ATP2A2 (NP_733765.1). |
Sequence: | MENA HTKT VEEV LGHF GVNE STGL SLEQ VKKL KERW GSNE LPAE EGKT LLEL VIEQ FEDL LVRI LLLA ACIS FVLA WFEE |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:2000 - 1:10000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | DD; DAR; ATP2B; SERCA2; SERCA2/ATP2A2 |
Positive Sample: | 293T,NIH/3T3,Mouse heart,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Multi-pass membrane protein, Sarcoplasmic reticulum membrane. |
Calculated MW: | 115kDa |
Observed MW: | 115kDa |
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of the skeletal muscle. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Other types of mutations in this gene have been associated with various forms of muscular dystrophies. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 488 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |