The ATP2A2 Polyclonal Antibody (CAB1097) is a valuable tool for researchers studying ATP2A2, a protein involved in calcium transport and regulation in cells. This antibody is raised in rabbits and is highly specific to human samples, making it ideal for use in Western blot applications.ATP2A2, also known as SERCA2, is a crucial player in maintaining calcium homeostasis and regulating muscle contraction. Dysregulation of ATP2A2 has been linked to various diseases, including heart failure, muscular dystrophy, and neurodegenerative disorders.
By targeting ATP2A2 with this antibody, researchers can investigate its expression levels and function in different cell types and tissues.The ATP2A2 Polyclonal Antibody (CAB1097) offers a reliable tool for understanding the role of ATP2A2 in cellular physiology and disease pathology. Its high reactivity and specificity make it a valuable asset for studies in molecular biology, biochemistry, and medical research.
Product Name:
SERCA2/ATP2A2 Rabbit Polyclonal Antibody
SKU:
CAB1097
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence within amino acids 1-80 of human SERCA2/ATP2A2 (NP_733765.1).
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of the skeletal muscle. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Other types of mutations in this gene have been associated with various forms of muscular dystrophies. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
488
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using SERCA2/ATP2A2 Rabbit pAb (CAB1097) at 1:10000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
