The ATP23 Polyclonal Antibody (CAB12885) is a vital tool for research involving ATP23, a protein involved in mitochondrial function and homeostasis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting. By binding specifically to the ATP23 protein, researchers can accurately detect and analyze its expression in different cell types, making it an essential component for studies in mitochondrial biology and related diseases. ATP23, a member of the ATPase family, plays a crucial role in the maintenance of mitochondrial membrane integrity and function.
Dysregulation of ATP23 has been linked to mitochondrial dysfunction and various diseases, including neurodegenerative disorders and metabolic syndromes. Understanding the function and regulation of ATP23 is essential for developing targeted therapies and interventions to address these conditions effectively. The ATP23 Polyclonal Antibody provides researchers with a powerful tool to investigate the role of ATP23 in mitochondrial physiology and its implications for human health.
Product Name:
ATP23 Rabbit Polyclonal Antibody
SKU:
CAB12885
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-246 of human ATP23 (NP_150592.1).
cytosol, extrinsic component of mitochondrial inner membrane, plasma membrane
Calculated MW:
28kDa
Observed MW:
28kDa
The protein encoded by this gene is amplified in glioblastomas and interacts with the DNA binding subunit of DNA-dependent protein kinase. This kinase is involved in double-strand break repair (DSB), and higher expression of the encoded protein increases the efficiency of DSB. In addition, comparison to orthologous proteins strongly suggests that this protein is a metalloprotease important in the biosynthesis of mitochondrial ATPase. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
91419
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ATP23 Rabbit pAb (CAB12885) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
