The ATP1B1 Polyclonal Antibody (CAB5793) is a valuable tool for researchers studying ATP1B1, a crucial protein involved in ion transport and cell signaling processes. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the ATP1B1 protein, researchers can accurately detect and analyze its expression in various cell types, making it ideal for studies in physiology, cell biology, and neuroscience.ATP1B1, a subunit of the Na+/K+-ATPase pump, plays a fundamental role in maintaining cell membrane potential and ion gradients essential for cellular function.
Dysregulation of ATP1B1 has been linked to various diseases such as neurological disorders, cardiovascular diseases, and cancer. Therefore, understanding the expression and function of ATP1B1 is crucial for advancing research in these areas and developing targeted therapies.Overall, the ATP1B1 Polyclonal Antibody (CAB5793) offers a reliable and specific tool for investigating the role of ATP1B1 in cellular processes and disease pathogenesis, making it a valuable asset for researchers in the fields of biochemistry, molecular biology, and medicine.
Product Name:
ATP1B1 Rabbit Polyclonal Antibody
SKU:
CAB5793
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 63-303 of human ATP1B1 (NP_001668.1).
Cell membrane, Single-pass type II membrane protein.
Calculated MW:
35kDa
Observed MW:
55kDa
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known.
Purification Method:
Affinity purification
Gene ID:
481
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ATP1B1 Rabbit pAb (CAB5793) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
