The ATP1B1 Polyclonal Antibody (CAB12403) is a vital tool for researchers studying ATP1B1, a crucial subunit of the sodium-potassium pump responsible for maintaining cellular ion balance. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for Western blot applications. By specifically binding to the ATP1B1 protein, researchers can accurately detect and analyze its expression in various cell types, making it an excellent choice for studies in the fields of cell biology and physiology.ATP1B1 is a key player in cellular function, serving as a pivotal component in the regulation of ion transport and cell signaling.
Dysregulation of ATP1B1 has been linked to various diseases, such as hypertension, neurological disorders, and cardiac conditions, highlighting its importance in maintaining physiological homeostasis. By investigating the role of ATP1B1, researchers can gain valuable insights into disease mechanisms and potentially develop targeted therapies to treat associated disorders.Overall, the ATP1B1 Polyclonal Antibody (CAB12403) offers researchers a reliable tool for investigating the function and regulation of ATP1B1, paving the way for further advancements in understanding cellular physiology and disease pathology.
Product Name:
ATP1B1 Rabbit Polyclonal Antibody
SKU:
CAB12403
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 65-240 of human ATP1B1 (NP_001668.1).
Cell membrane, Single-pass type II membrane protein.
Calculated MW:
35kDa
Observed MW:
50kDa
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known.
Purification Method:
Affinity purification
Gene ID:
481
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ATP1B1 Rabbit pAb (CAB12403) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
