The ATP1A2 Polyclonal Antibody (CAB13805) is a valuable tool for researchers studying the ATP1A2 protein, a key component of the sodium-potassium pump essential for maintaining cell membrane potential and cellular homeostasis. This antibody, produced through immunization of rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.ATP1A2, a member of the P-type ATPase family, is a critical enzyme involved in ion transport across cell membranes and plays a crucial role in the function of excitable cells like neurons and muscle cells.
Dysregulation of ATP1A2 has been linked to neurological disorders such as familial hemiplegic migraine and epilepsy, making it an important target for research in neuroscience and pharmacology.By using the ATP1A2 Polyclonal Antibody, researchers can detect and analyze the expression of ATP1A2 in various cell types, providing insights into its role in cellular physiology and disease pathology. This antibody is an invaluable tool for advancing our understanding of ion transport mechanisms and their implications for human health.
Product Name:
ATP1A2 Rabbit Polyclonal Antibody
SKU:
CAB13805
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human ATP1A2 (NP_000693.1).
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood.
Purification Method:
Affinity purification
Gene ID:
477
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of Mouse skeletal muscle, using ATP1A2 antibody (CAB13805) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
