The ATP1A1 Antibody (PACO23621) is a valuable tool for researchers studying the ATP1A1 protein, which is a critical component of the sodium-potassium pump that maintains the electrochemical gradient across cell membranes. This polyclonal antibody, generated using rabbits, has high specificity for human samples and is validated for use in Western blot applications.The ATP1A1 Antibody binds specifically to the ATP1A1 protein, allowing for accurate detection and analysis in a variety of cell types. This makes it an excellent choice for studies in cell biology, physiology, and biochemistry, where the role of ATP1A1 in cellular functions and disease processes is of interest.
ATP1A1 is essential for proper cell function, as it plays a key role in maintaining ion balance and regulating cell volume. Dysregulation of ATP1A1 activity has been linked to various diseases, including hypertension, heart failure, and neurological disorders. By studying the function of ATP1A1 using this antibody, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.
Synthesized non-phosphopeptide derived from human ATP1 alpha 1/Na+K+ ATPase1 around the phosphorylation site of serine 23 (K-K-S(p)-K-K).
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunofluorescence analysis of HeLa cells, using ATP1alpha 1/Na+K+ ATPase1 (Ab-23) antibody.
Western blot analysis of extracts from K562 cells (Lane 2), using ATP1 alpha 1/Na+K+ ATPase1 (Ab-23) antiobdy. The lane on the left is treated with synthesized peptide.
Western blot analysis of extracts from HeLa cells, using ATP1 alpha 1/Na+K+ ATPase1 (Ab-23) antibody.
Background:
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
UniProt Protein Details:
NCBI Summary:
mediates Na+ and K+ transport; may play a role in regulation of blood pressure [RGD, Feb 2006]
