The ATP13A2 Polyclonal Antibody (CAB13083) is designed for research involving ATP13A2, a member of the P-type ATPase family of proteins implicated in neurodegenerative disorders, specifically Parkinson's disease. The antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.ATP13A2, also known as PARK9, functions as a lysosomal ATPase involved in maintaining lysosomal pH and metal ion homeostasis. Mutations in the ATP13A2 gene have been linked to lysosomal dysfunction and the pathogenesis of Parkinson's disease, highlighting its importance in neuronal health and survival.
Research on ATP13A2 is crucial for understanding the mechanisms underlying neurodegeneration and developing potential therapeutic strategies for treating Parkinson's disease and related disorders.Overall, the ATP13A2 Polyclonal Antibody offers researchers a valuable tool for studying the role of ATP13A2 in neurodegenerative diseases and advancing our knowledge of lysosomal function in the context of neuroprotection. Its specificity and sensitivity make it an essential component in research projects focused on elucidating the molecular pathways involved in Parkinson's disease pathology.
Product Name:
ATP13A2 Rabbit Polyclonal Antibody
SKU:
CAB13083
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 70-210 of human ATP13A2 (NP_071372.1).
This gene encodes a member of the P5 subfamily of ATPases which transports inorganic cations as well as other substrates. Mutations in this gene are associated with Kufor-Rakeb syndrome (KRS), also referred to as Parkinson disease 9. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
23400
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse brain, using ATP13A2 Rabbit pAb (CAB13083) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
