The ATOX1 Polyclonal Antibody (CAB6874) is a valuable tool for researchers studying ATOX1, a copper-binding protein involved in copper transport and homeostasis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the ATOX1 protein, researchers can accurately detect and analyze ATOX1 levels in a variety of cell types, making it an excellent choice for studies in molecular biology and copper metabolism research.ATOX1 plays a crucial role in copper trafficking within cells, facilitating the delivery of copper to various enzymes and proteins essential for cellular functions.
Dysregulation of ATOX1 has been implicated in diseases associated with copper imbalance, such as Wilson's disease and Menkes disease. Understanding the function of ATOX1 is key to uncovering its role in these disorders and developing targeted therapies for copper-related conditions. The ATOX1 Polyclonal Antibody provides researchers with a reliable tool for investigating the intricate mechanisms of copper homeostasis and its implications in human health.
Product Name:
ATOX1 Rabbit Polyclonal Antibody
SKU:
CAB6874
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-68 of human ATOX1 (NP_004036.1).
This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome.
Purification Method:
Affinity purification
Gene ID:
475
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ATOX1 Antibody (CAB6874) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
