Atoh1 Antibody (PACO25120)
- SKU:
- PACO25120
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Atoh1 Antibody (PACO25120)
The ATOH1 Antibody (PAC025120) is a polyclonal antibody designed for research involving the ATOH1 protein, a key transcription factor essential for the development and differentiation of sensory and secretory cells in the inner ear and gut. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in various applications, including immunofluorescence and Western blotting.ATOH1, also known as Math1, is a crucial regulator of cell fate determination and differentiation in the development of various tissues. Its role in generating sensory hair cells in the inner ear and secretory cells in the gut highlights its importance in physiological processes such as hearing and digestion.
Research on ATOH1 is essential for understanding cell differentiation mechanisms and potential therapeutic targets for hearing loss and gastrointestinal disorders. The ATOH1 Antibody (PAC025120) enables precise detection and analysis of ATOH1 protein expression in different cell types, providing valuable insights for studies in developmental biology, regenerative medicine, and disease mechanisms. Its high specificity and reliability make it a powerful tool for researchers investigating the intricate mechanisms of cell differentiation and tissue development.
| Antibody Name: | Atoh1 Antibody (PACO25120) |
| Antibody SKU: | PACO25120 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant Mouse Protein atonal homolog 1 protein (1-351AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot Positive WB detected in: Mouse kidney tissue All lanes: Atoh1 antibody at 3.4µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 38 kDa Observed band size: 38 kDa . |
| Background: | Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription. |
| Synonyms: | Protein atonal homolog 1 (Helix-loop-helix protein mATH-1) (mATH1), Atoh1, Ath1 |
| UniProt Protein Function: | Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P48985 |
| NCBI GenInfo Identifier: | 6680742 |
| NCBI Gene ID: | 11921 |
| NCBI Accession: | NP_031526.1 |
| UniProt Secondary Accession: | P48985 |
| UniProt Related Accession: | P48985 |
| Molecular Weight: | 41.9 kDa |
| NCBI Full Name: | protein atonal homolog 1 |
| NCBI Synonym Full Names: | atonal bHLH transcription factor 1 |
| NCBI Official Symbol: | Atoh1Â Â |
| NCBI Official Synonym Symbols: | Hath1; Math1; MATH-1; bHLHa14Â Â |
| NCBI Protein Information: | protein atonal homolog 1 |
| UniProt Protein Name: | Protein atonal homolog 1 |
| UniProt Synonym Protein Names: | Helix-loop-helix protein mATH-1; mATH1 |
| Protein Family: | Protein atonal |
| UniProt Gene Name: | Atoh1Â Â |
| UniProt Entry Name: |
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