The ATN1 Antibody (PACO00445) is a polyclonal antibody specifically designed for research involving ATN1, a protein associated with neurological disorders such as dentatorubral-pallidoluysian atrophy (DRPLA) and autism spectrum disorders. This antibody is produced in rabbits and is highly reactive with human samples, making it suitable for use in Western blot applications.ATN1, also known as Atrophin-1, is a transcriptional corepressor that plays a critical role in neural development and gene expression regulation. Mutations in the ATN1 gene have been linked to the pathogenesis of neurological conditions, making it a promising target for therapeutic research.
By binding to the ATN1 protein, this antibody enables the detection and analysis of ATN1 expression in various cell types, providing valuable insights into its function and potential implications in disease pathogenesis. Researchers studying neurological disorders and gene regulation will find this antibody essential for their studies, offering opportunities for novel discoveries and therapeutic advancements in the field.
Antibody Name:
ATN1 Antibody
Antibody SKU:
PACO00445
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the N-terminal region of human Atrophin-1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
ATN1; D12S755E; DRPLA; Atrophin-1; Dentatorubral-pallidoluysian atrophy protein
UniProt Protein Function:
DRPLA: a protein that interacts with the E3 ubiquitin-protein ligase WWP1 and WWP2. May be involved in the third step of ubiquitin conjugation. Relatively high levels in the brain, ovary, testis and prostate. Lower levels in the liver, thymus and leukocytes. Defects are the cause of the neurodegenerative disorders dentatorubral-pallidoluysian atrophy (DRPLA) and Haw River syndrome (HRS).Protein type: Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 12p13.31Cellular Component: cell junction; cytoplasm; nuclear matrix; nucleoplasm; nucleus; perinuclear region of cytoplasmMolecular Function: protein binding; protein domain specific binding; transcription corepressor activityBiological Process: central nervous system development; negative regulation of transcription from RNA polymerase II promoter; neuron apoptosis; transcription, DNA-dependentDisease: Dentatorubral-pallidoluysian Atrophy
UniProt Protein Details:
NCBI Summary:
Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-23 copies to 49-75 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein. [provided by RefSeq, Feb 2010]
