The Atlastin-3 Polyclonal Antibody (CAB12196) is a valuable tool for researchers studying Atlastin-3, a protein involved in regulating membrane fusion in the endoplasmic reticulum. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to Atlastin-3, this antibody allows for the detection and analysis of this important protein in a variety of cell types, making it ideal for studies in cell biology and neurology.Atlastin-3 plays a crucial role in maintaining the structure and function of the endoplasmic reticulum, a critical organelle involved in protein synthesis and lipid metabolism.
Dysregulation of Atlastin-3 has been implicated in neurodegenerative diseases such as hereditary spastic paraplegia, highlighting the importance of understanding its function. By studying Atlastin-3 using this antibody, researchers can gain insights into the mechanisms underlying these disorders and potentially identify new therapeutic strategies.
Product Name:
ATL3 Rabbit Polyclonal Antibody
SKU:
CAB12196
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 360-440 of human ATL3 (NP_056274.3).
This gene encodes a member of a family of dynamin-like, integral membrane GTPases. The encoded protein is required for the proper formation of the network of interconnected tubules of the endoplasmic reticulum. Mutations in this gene may be associated with hereditary sensory neuropathy type IF. Alternatively spliced transcript variants that encode distinct isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
25923
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ATL3 Rabbit pAb (CAB12196) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
