The Atlastin-1 Polyclonal Antibody (CAB5302) is a vital tool for researchers studying the Atlastin-1 protein, which plays a crucial role in the maintenance of the endoplasmic reticulum (ER) network. This antibody is raised in rabbits and shows high reactivity with human samples, making it an excellent choice for a variety of research applications.Atlastin-1 is a GTPase protein involved in the fusion of ER membranes, essential for proper ER structure and function. Dysregulation of Atlastin-1 has been linked to neurodegenerative diseases such as hereditary spastic paraplegia. By using the Atlastin-1 Polyclonal Antibody, researchers can detect and analyze Atlastin-1 levels in different cell types, aiding in the study of ER dynamics and potential therapeutic targets for related disorders.
With its specificity and reliability in Western blot applications, this antibody is a valuable tool for researchers in the fields of cell biology, neuroscience, and neurology. Understanding the role of Atlastin-1 in cellular physiology and disease pathogenesis is crucial for advancing knowledge and developing targeted treatments for a range of neurodegenerative conditions.
Product Name:
ATL1 Rabbit Polyclonal Antibody
SKU:
CAB5302
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ATL1 (NP_056999.2).
The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
51062
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ATL1 antibody (CAB5302) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
