The ATGL (PNPLA2) Rabbit Monoclonal Antibody (CAB5126) is a valuable tool for researchers studying adipose triglyceride lipase (ATGL), also known as patatin-like phospholipase domain-containing protein 2 (PNPLA2). This antibody, produced in rabbits, has high reactivity with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.ATGL is a key enzyme involved in lipid metabolism, specifically in the hydrolysis of triacylglycerol stored in adipose tissue. Dysregulation of ATGL has been linked to metabolic disorders such as obesity and insulin resistance, making it a promising target for therapeutic interventions.
The ATGL (PNPLA2) Rabbit Monoclonal Antibody enables the detection and analysis of ATGL protein levels in different cell types, providing valuable insights into its role in lipid catabolism and potential implications in metabolic diseases.Researchers in the fields of biochemistry, metabolism, and obesity-related research will find this antibody particularly useful for investigating the molecular mechanisms underlying lipid metabolism and metabolic disorders. By understanding the function of ATGL at the protein level, researchers can further explore its potential as a therapeutic target for conditions associated with dysregulated lipid metabolism.
Product Name:
ATGL/PNPLA2 Rabbit Monoclonal Antibody
SKU:
CAB5126
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 300-394 of human ATGL / PNPLA2 (NP_065109.1).
Cell membrane, Lipid droplet, Single-pass type II membrane protein.
Calculated MW:
55kDa
Observed MW:
55kDa
This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy.
Purification Method:
Affinity purification
Gene ID:
57104
Clone Number:
ARC1192
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using ATGL/PNPLA2 Rabbit mAb (CAB5126) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
