The ATG8 Antibody (PAC036682) is a valuable tool for research involving the ATG8 protein, a key player in the autophagy pathway. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By specifically binding to the ATG8 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for studies focused on autophagy, cell biology, and disease mechanisms.ATG8 is a critical component of the autophagy process, responsible for autophagosome formation and cargo recognition. Dysregulation of autophagy has been linked to a range of diseases, including cancer, neurodegenerative disorders, and metabolic conditions.
By studying the function and regulation of ATG8, researchers can gain insights into the underlying mechanisms of these diseases and identify potential therapeutic targets for intervention.With its high specificity and reliability, the ATG8 Antibody (PAC036682) is a valuable tool for scientists seeking to explore the role of autophagy in health and disease. Whether investigating basic cellular processes or developing novel treatments, this antibody provides a critical resource for advancing our understanding of autophagy biology.
Antibody Name:
ATG8 Antibody (PACO36682)
Antibody SKU:
PACO36682
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Candida glabrata
Immunogen:
Recombinant Candida glabrata Autophagy-related protein 8 protein (1-116AA)
Ubiquitin-like modifier involved in cytoplasm to vacuole transport (Cvt) vesicles and autophagosomes formation. With ATG4, mediates the delivery of the vesicles and autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.
Synonyms:
Autophagy-related protein 8 (Autophagy-related ubiquitin-like modifier ATG8), ATG8, AUT7
UniProt Protein Function:
Ubiquitin-like modifier involved in autophagosomes formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.
