The ATG7 Polyclonal Antibody (CAB0691) is a valuable tool for researchers studying autophagy, a cellular process involved in the degradation and recycling of cellular components. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.ATG7 is a key protein involved in the initiation of autophagy, playing a critical role in the formation of autophagosomes. Dysfunction in the autophagy pathway has been linked to a range of diseases, including cancer, neurodegenerative disorders, and metabolic conditions.
By targeting ATG7 with this antibody, researchers can gain valuable insights into the regulation of autophagy and its implications for disease development.With its high reactivity and specificity, the ATG7 Polyclonal Antibody is a valuable tool for studying the intricate mechanisms of autophagy and its impact on cellular homeostasis. Researchers in the fields of cell biology, cancer biology, and neurobiology will find this antibody essential for their studies.
Product Name:
ATG7 Rabbit Polyclonal Antibody
SKU:
CAB0691
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 500-676 of human ATG7 (NP_006386.1).
This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
10533
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma using ATG7 Rabbit pAb (CAB0691) at dilution of 1:50 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
