The ATG4B Polyclonal Antibody (CAB2837) is a powerful tool for researchers studying ATG4B, a key player in the autophagy process. Autophagy is a cellular mechanism that clears out damaged or unnecessary components, playing a crucial role in maintaining cellular health and preventing diseases like cancer and neurodegenerative disorders.This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the ATG4B protein, this antibody allows for the detection and analysis of ATG4B in various cell types, providing valuable insights into the autophagy pathway.
ATG4B is a critical enzyme involved in the processing of proteins during autophagy, making it a promising target for therapeutic interventions aimed at enhancing or inhibiting autophagy in disease states. Research into ATG4B function and regulation is key to developing treatments for conditions associated with dysregulated autophagy, making this antibody an essential tool for advancing our understanding of autophagy-related diseases.
Product Name:
ATG4B Rabbit Polyclonal Antibody
SKU:
CAB2837
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant Protein corresponding to a sequence within amino acids 1-393 of human ATG4B (NP_037457.3).
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Purification Method:
Affinity purification
Gene ID:
23192
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from RD cells using ATG4B Rabbit pAb(CAB2837) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
