The ATG4A Polyclonal Antibody (CAB2598) is a vital tool for researchers studying ATG4A, a key player in the autophagy process essential for maintaining cellular homeostasis. This antibody, produced in rabbits, demonstrates high specificity and reactivity towards human ATG4A, making it suitable for Western blot applications. By binding specifically to the ATG4A protein, researchers can accurately detect and analyze its expression in a variety of cell types, offering insights into autophagy mechanisms and potential therapeutic targets.
ATG4A is a crucial regulator of autophagy, a cellular process involved in removing damaged organelles and proteins to maintain cell health and prevent disease development. Dysregulation of autophagy, often seen in cancer and neurodegenerative disorders, underscores the importance of understanding ATG4A function. Research using this antibody may lead to breakthroughs in developing treatments targeting autophagy-related conditions, offering hope for improved patient outcomes in the future.
Product Name:
ATG4A Rabbit Polyclonal Antibody
SKU:
CAB2598
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 210-398 of human ATG4A (NP_443168.2).
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases.
Purification Method:
Affinity purification
Gene ID:
115201
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ATG4A antibody (CAB2598) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
