Anti-ATG16L1 Antibody (CAB14138)
- SKU:
- CAB14138
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Autophagy
Frequently bought together:
Description
| Antibody Name: | Anti-ATG16L1 Antibody |
| Antibody SKU: | CAB14138 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human ATG16L1 (NP_110430.5). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human ATG16L1 (NP_110430.5). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QEAN RLNA ENEK DSRR RQAR LQKE LAEA AKEP LPVE QDDD IEVI VDET SDHT EETS PVRA ISRA ATKR LSQP AGGL LDSI TNIF GRRS VSSF PVPQ DNVD T |
| Gene ID: | 55054 |
| Uniprot: | Q676U5 |
| Cellular Location: | Cytoplasm, Peripheral membrane protein, Preautophagosomal structure membrane |
| Calculated MW: | 47kDa/49kDa/53kDa/66kDa/68kDa |
| Observed MW: | Refer to figures |
| Synonyms: | ATG16L1, APG16L, ATG16A, ATG16L, IBD10, WDR30 |
| Background: | The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | ATG16L1: Plays an essential role in autophagy. Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). Belongs to the WD repeat ATG16 family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, peripheral; Adaptor/scaffold; Autophagy Chromosomal Location of Human Ortholog: 2q37.1 Cellular Component: autophagic vacuole; axoneme; cytosol Molecular Function:identical protein binding; protein binding; small conjugating protein ligase activity Biological Process: autophagic vacuole formation; macroautophagy Disease: Inflammatory Bowel Disease 10 |
| NCBI Summary: | The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010] |
| UniProt Code: | Q676U5 |
| NCBI GenInfo Identifier: | 62510482 |
| NCBI Gene ID: | 55054 |
| NCBI Accession: | Q676U5.2 |
| UniProt Secondary Accession: | Q676U5,Q6IPN1, Q6UXW4, Q6ZVZ5, Q8NCY2, Q96JV5, Q9H619 A3EXK9, A3EXL0, B6ZDH0, |
| UniProt Related Accession: | Q676U5 |
| Molecular Weight: | 49,486 Da |
| NCBI Full Name: | Autophagy-related protein 16-1 |
| NCBI Synonym Full Names: | autophagy related 16 like 1 |
| NCBI Official Symbol: | ATG16L1Â Â |
| NCBI Official Synonym Symbols: | IBD10; WDR30; APG16L; ATG16A; ATG16LÂ Â |
| NCBI Protein Information: | autophagy-related protein 16-1 |
| UniProt Protein Name: | Autophagy-related protein 16-1 |
| UniProt Synonym Protein Names: | APG16-like 1 |
| Protein Family: | Autophagy-related protein |
| UniProt Gene Name: | ATG16L1Â Â |
| UniProt Entry Name: | A16L1_HUMAN |
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