The ATG1 antibody (PACO36678) is a high-quality polyclonal antibody designed for research involving ATG1, a key protein involved in autophagy regulation. This antibody, raised in rabbit hosts, is specifically reactive with human samples and has been validated for use in Western blot applications. By binding to the ATG1 protein, this antibody allows for the accurate detection and analysis of ATG1 levels in various cell types.ATG1 is a crucial protein in the autophagy process, a cellular mechanism responsible for degrading and recycling unnecessary or dysfunctional components. Dysregulation of autophagy has been implicated in various diseases, making ATG1 an important target for research in fields such as cancer, neurodegenerative disorders, and metabolic diseases.
Understanding the functions and regulation of ATG1 is essential for the development of potential therapies targeting autophagy pathways.Overall, the ATG1 antibody is a valuable tool for researchers studying autophagy and its role in disease pathogenesis. Its high reactivity and specificity in detecting ATG1 make it an ideal choice for experiments in cell biology, molecular biology, and drug discovery.
Antibody Name:
ATG1 Antibody (PACO36678)
Antibody SKU:
PACO36678
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Candida glabrata
Immunogen:
Recombinant Candida glabrata Serine/threonine-protein kinase ATG1 protein (11-312AA)
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9.
Synonyms:
Serine/threonine-protein kinase ATG1 (EC 2.7.11.1) (Autophagy-related protein 1), ATG1
UniProt Protein Function:
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9.
