ATF6B Rabbit Polyclonal Antibody (CAB16742)
- SKU:
- CAB16742
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | ATF6B Rabbit Polyclonal Antibody |
SKU: | CAB16742 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human ATF6B (Q99941). |
Sequence: | MAEL MLLS EIAD PTRF FTDN LLSP EDWG LQNS TLYS GLDE VAEE QTQL FRCP EQDV PFDG SSLD VGMD VS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | G13; CREBL1; CREB-RP; ATF6B |
Positive Sample: | mouse lung,mouse brain |
Cellular Localization: | Golgi apparatus, nucleus |
Calculated MW: | 77kDa |
Observed MW: | 70kDa |
The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 1388 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |