ATF6 Polyclonal Antibody (CAB12570)
- SKU:
- CAB12570
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | ATF6 Polyclonal Antibody |
SKU: | CAB12570 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 600-670 of human ATF6 (NP_031374.2). |
Sequence: | INEN VING QDYE VMMQ IDCQ VMDT RILH IKSS SVPP YLRD QQRN QTNT FFGS PPAA TEAT HVVS TIPE SLQ |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | ACHM7; ATF6A; ATF6 |
Positive Sample: | K-562,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Nucleus, Single-pass type II membrane protein. |
Calculated MW: | 75kDa |
Observed MW: | 92kDa |
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.
Purification Method: | Affinity purification |
Gene ID: | 22926 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |