ATF6 Rabbit Polyclonal Antibody (CAB0202)
- SKU:
- CAB0202
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | ATF6 Rabbit Polyclonal Antibody |
SKU: | CAB0202 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 190-300 of human ATF6 (NP_031374.2). |
Sequence: | PKTQ TNSS VPAK TIII QTVP TLMP LAKQ QPII SLQP APTK GQTV LLSQ PTVV QLQA PGVL PSAQ PVLA VAGG VTQL PNHV VNVV PAPS ANSP VNGK LSVT KPVL QSTM RNV |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 IHC-P,1:50 - 1:200 |
Synonyms: | ACHM7; ATF6A; ATF6 |
Positive Sample: | Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Nucleus, Single-pass type II membrane protein. |
Calculated MW: | 75kDa |
Observed MW: | 90-100kDa |
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.
Purification Method: | Affinity purification |
Gene ID: | 22926 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |