The ATF6 Polyclonal Antibody (CAB0202) is a valuable tool for research involving ATF6, a key regulatory protein in the unfolded protein response pathway. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to ATF6, researchers can detect and analyze this important protein in a variety of cell types, making it ideal for studies in molecular biology and disease research.ATF6, also known as activating transcription factor 6, plays a crucial role in the cellular stress response by regulating the expression of genes involved in protein folding and quality control.
Dysregulation of ATF6 has been implicated in various diseases, including neurodegenerative disorders, diabetes, and cardiovascular disease. Understanding the function of ATF6 is essential for developing targeted therapies that modulate the unfolded protein response and alleviate stress-related pathologies.Overall, the ATF6 Polyclonal Antibody (CAB0202) is a reliable tool for investigating the role of ATF6 in cellular stress and disease pathogenesis, offering valuable insights into potential therapeutic strategies.
Product Name:
ATF6 Rabbit Polyclonal Antibody
SKU:
CAB0202
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 190-300 of human ATF6 (NP_031374.2).
Endoplasmic reticulum membrane, Nucleus, Single-pass type II membrane protein.
Calculated MW:
75kDa
Observed MW:
90-100kDa
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.
Purification Method:
Affinity purification
Gene ID:
22926
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat lung using ATF6 Rabbit pAb(CAB0202) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
