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ATF5 Transcription Factor Activity Assay

SKU:
TFAB00085
Product Type:
ELISA Kit
ELISA Type:
Transcription Factor Assay
Analytes:
ATF5
Reactivity:
Human
€599
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Description

system_update_altDatasheet

ATF5 Transcription Factor Activity Assay

The ATF5 Transcription Factor Activity Assay is a powerful tool for researchers studying transcriptional regulation and gene expression. This assay kit allows for the accurate measurement of ATF5 activity in cell lysates or nuclear extracts, providing valuable insights into the role of ATF5 in various cellular processes.ATF5 is a transcription factor that plays a key role in regulating gene expression in response to cellular stress, making it a critical mediator of cell survival and proliferation. Dysregulation of ATF5 has been implicated in a variety of diseases, including cancer and neurodegenerative disorders, highlighting its importance as a potential therapeutic target.

The ATF5 Transcription Factor Activity Assay offers high sensitivity and specificity, ensuring precise and reliable results that can be easily quantified using a microplate reader. By tracking ATF5 activity, researchers can gain a better understanding of its impact on gene expression and potentially identify novel treatment strategies for diseases associated with ATF5 dysregulation.

Product Name:ATF5 Transcription Factor Activity Assay
Product Code:TFAB00085
Target:ATF5
Reactivity:Human
Sample Types:Nuclear or cell lysates

The Assay Genie ATF5 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates

Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.

Assay Time:4.5 hours
Detection Method:Colorimetric 450 nm
Size:12 x 8-Well Microstrips
Storage:4°C for 6 months
UniProt Protein Function:ATF-5: Transcriptional activator which binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4. Belongs to the bZIP family.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: centrosome; cytoplasm; nucleoplasm; nucleus

Molecular Function:chromatin binding; kinase binding; protein binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity; tubulin binding

Biological Process: fat cell differentiation; granule cell precursor proliferation; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of centrosome cycle; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent

UniProt Code:Q9Y2D1
NCBI GenInfo Identifier:308153647
NCBI Gene ID:22809
NCBI Accession:Q9Y2D1.4
UniProt Secondary Accession:Q9Y2D1,Q9BSA1, Q9UNQ3, B3KND3,
UniProt Related Accession:Q9Y2D1
Molecular Weight:30,674 Da
NCBI Full Name:Cyclic AMP-dependent transcription factor ATF-5
NCBI Synonym Full Names:activating transcription factor 5
NCBI Official Symbol:ATF5  
NCBI Official Synonym Symbols:ATFX; HMFN0395  
NCBI Protein Information:cyclic AMP-dependent transcription factor ATF-5
UniProt Protein Name:Cyclic AMP-dependent transcription factor ATF-5
UniProt Synonym Protein Names:Activating transcription factor 5; Transcription factor ATFx
Protein Family:Cyclic AMP-dependent transcription factor
UniProt Gene Name:ATF5  
UniProt Entry Name:ATF5_HUMAN
AntibodiesELISA Kits
Anti-ATF5 Antibody (CAB18155)Human ATF5 (Activating Transcription Factor 5) ELISA Kit (HUES01721)
ATF5 Antibody (PACO00437)
Acetyl-ATF5 (K29) Antibody (PACO06056)
ATF5 Antibody (PACO21989)
ATF5 Antibody (PACO63255)

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