The ATF3 Polyclonal Antibody (CAB13469) is a valuable tool for researchers studying ATF3, a key transcription factor involved in the cellular response to stress and inflammation. This polyclonal antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the ATF3 protein, this antibody enables precise detection and analysis in a variety of cell types, making it well-suited for investigations in molecular biology and disease research.ATF3, also known as activating transcription factor 3, is a pivotal regulator of gene expression in response to various stress stimuli, playing a crucial role in determining cellular fate under adverse conditions.
Its involvement in pathways related to inflammation, cell proliferation, and apoptosis makes it a compelling target for studying diseases such as cancer, neurodegenerative disorders, and metabolic syndromes. Uncovering the mechanisms by which ATF3 functions can provide valuable insights for developing therapeutic strategies that target these disease processes.
Product Name:
ATF3 Rabbit Polyclonal Antibody
SKU:
CAB13469
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human ATF3 (NP_001665.1).
This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes.
Purification Method:
Affinity purification
Gene ID:
467
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from 293T cells, using ATF3 Rabbit pAb (CAB13469) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
