ATF1 Rabbit Polyclonal Antibody (CAB5791)
- SKU:
- CAB5791
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | ATF1 Rabbit Polyclonal Antibody |
SKU: | CAB5791 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human ATF1 (NP_005162.1). |
Sequence: | MEDS HKST TSET APQP GSAV QGAH ISHI AQQV SSLS ESEE SQDS SDSI GSSQ KAHG ILAR RPSY RKIL KDLS SEDT RGRK GDGE NSGV SAAV TSMS VPTP IYQT SSGQ YIAI APNG ALQL ASPG TDGV QGLQ TLTM TNSG STQQ GTTI LQYA QTSD GQQI LVPS NQVV VQTA SGDM QTYQ IRTT PSAT SLPQ TVVM TSPV TLTS QTTK TD |
Tested Applications: | WB IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | TREB36; EWS-ATF1; FUS/ATF-1; ATF1 |
Positive Sample: | HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 29kDa |
Observed MW: | 36kDa |
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.
Purification Method: | Affinity purification |
Gene ID: | 466 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |