The Ataxin-3 Polyclonal Antibody (CAB1243) is a valuable tool for researchers studying Ataxin-3, a protein involved in neurodegenerative diseases such as spinocerebellar ataxia type 3 (SCA3). This antibody, produced in rabbits, has high specificity for human samples and is suitable for use in Western blotting and immunohistochemistry applications.Ataxin-3 is a key player in the pathogenesis of SCA3, a progressive disorder affecting coordination and movement control. By targeting Ataxin-3, researchers can investigate the mechanisms underlying disease development and progression, potentially leading to new therapeutic strategies for managing SCA3 and other related conditions.
The Ataxin-3 Polyclonal Antibody enables precise detection and analysis of Ataxin-3 protein levels in various cell types and tissue samples, making it an essential tool for studies in neuroscience, neurology, and molecular biology. By exploring the role of Ataxin-3 in disease processes, researchers can gain valuable insights into the pathophysiology of SCA3 and potentially uncover novel targets for intervention and treatment.
Product Name:
Ataxin 3 Rabbit Polyclonal Antibody
SKU:
CAB1243
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-361 of human Ataxin-3 (ATXN3) (NP_004984.2).
Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
4287
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Ataxin-3 (ATXN3) Rabbit pAb (CAB1243) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
