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Ataxin-3 (ATXN3) Monoclonal Antibody (CAB22094)

Datasheet MSDS
SKU CAB22094
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse, Rat
Host Species Rabbit
Synonyms AT3, JOS, MJD, ATX3, MJD1, SCA3, Ataxin-3 (ATXN3)
€131 - €457

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Description

system_update_altDatasheetsystem_update_altMSDS

Ataxin-3 (ATXN3) Monoclonal Antibody (CAB22094)

The Ataxin-3 (ATXN3) Monoclonal Antibody (CAB22094) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in mouse, is highly specific for human Ataxin-3 and is suitable for various applications including Western blot, immunofluorescence, and immunohistochemistry.Ataxin-3 is a deubiquitinating enzyme that plays a crucial role in protein degradation and maintenance of neuronal function. Mutations in the ATXN3 gene lead to the accumulation of toxic protein aggregates, which are hallmark features of SCA3 and other polyglutamine diseases.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Mouse, Rat samples.

Product Name:Ataxin-3 (ATXN3) Monoclonal Antibody
SKU:CAB22094
Size:20μL, 100μL
Reactivity:Mouse, Rat
Clone Number:ARC54882
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:KLIG EELA QLKE QRVH KTDL ERVL EAND GSGM LDED EEDL QRAL ALSR QEID MEDE EADL RRAI QLSM QGSS RNIS QDMT QTSG TNLT SEEL RKRR EAYF EKQQ QKQQ QQQQ QQQQ GDLS GQSS HPCE RPAT SSGA LGSD LGDA MSEE DMLQ AAVT MSLE TVRN DLKT EGKK
Tested Applications:WB ELISA
Recommended Dilution:
WB1:1000 - 1:5000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:AT3, JOS, MJD, ATX3, MJD1, SCA3, Ataxin-3 (ATXN3)
Positive Sample:Mouse brain, Rat brain
Cellular Localization:Nucleus Matrix.
Calculated MW:41kDa
Observed MW:42kDa

Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Purification MethodAffinity purification
Gene ID4287
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of extracts from various lysates, using Ataxin-3 (ATXN3) antibody (CAB22094) at 1:2000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.

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